Publications

Female rats self-administer heroin by vapor inhalation

Arnold Gutierrez, Jacques D. Nguyen, Kevin M. Creehan, Michael A. Taffe. Department of Neuroscience, The Scripps Research Insitute, La Jolla, CA, USA. Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.

Prenatal Alcohol and THC E-Cigarette Exposure Effects on Motor Development

Kristen R. Breit, Cristina Rodriguez, Annie Lei, Samirah Hussain, Jennifer D. Thomas.

Operant Vapor Self-Administration in Mice

Renata C. N. Marchette, Brendan J. Tunstall, Leandro F. Vendruscolo and Khaled Moussawi

Nicotine formulations impact reinforcement-related behaviors in a mouse model of vapor self-administration

Brandon J. Henderson, Skylar Y. Cooper. Department of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University.

Dissociable changes in spike and wave discharges following exposure to injected cannabinoids and smoked cannabis in Genetic Absence Epilepsy Rats from Strasbourg

Andrew J. Roebuck, Quentin Greba, Timothy J. Onofrychuck, Dan L. McElroy, Thaisa M Sandini, Ayat Zagzoog, Jonathan Simone, Stuart M. Cain, Terrance P. Snutch, Robert B. Laprairie, John G. Howland.

Broadly Neutralizing Synthetic Cannabinoid Vaccines

Mingliang Lin, Jinny Claire Lee, Steven Blake, Beverly Ellis, Lisa M. Eubanks, and Kim D. Janda

Fentanyl vapor self-administration model in mice to study opioid addiction

K. Moussawi, M. M. Ortiz, S. C. Gantz, B. J. Tunstall, R. C. N. Marchette, A. Bonci, G. F. Koob, L. F. Vendruscolo.

A vapor exposure method for delivering heroin alters nociception, body temperature and spontaneous activity in female and male rats

Gutierrez, A., Creehan, K.M., and Taffe, M.A. J Neurosci Methods, 2020.

Flavors enhance nicotine vapor self-administration in male mice

Skylar Y Cooper, Austin T Akers, Brandon J Henderson, PhD. - 1) Department of Biomedical Sciences, Joan C Edwards School of Medicine at Marshall University, Huntington, WV, USA.

Δ9-tetrahydrocannabinol Attenuates Oxycodone Self-Administration Under Extended Access Conditions

Jacques D. Nguyen, Yanabel Grant, Kevin M. Creehan, Candy S. Hwang, Sophia A. Vandewater, Kim D. Janda, Maury Cole, Michael Taffe. - 1) Department of Neuroscience; The Skaggs Institute for Chemical Biology, Worm Institute for Research and Medicine (WIRM); The Scripps Research Institute; La Jolla, CA. 2) Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute for Research and Medicine (WIRM); The Scripps Research Institute; La Jolla, CA. 3) La Jolla Alcohol Research Inc; La Jolla, CA. 4) Department of Chemistry, Southern Connecticut State University. 5) Department of Psychiatry, University of California, San Diego; La Jolla, CA.

Effects of ∆9 ‐tetrahydrocannabinol (THC) vapor inhalation in Sprague-Dawley and Wistar rats

Michael A. Taffe, Kevin M. Creehan, Sophia A Vandewater, Tony M. Kerr, Maury Cole. - 1) Department of Neuroscience, The Scripps Research Institute, La Jolla, California. 2) Department of Psychiatry, University of California San Diego, La Jolla, California. 3) La Jolla Alcohol Research, Inc., La Jolla, California.

Vaporized cannabis extracts have reinforcing properties and support conditioned drug-seeking behavior in rats

Timothy G. Freels, Lydia N. Baxter-Potter, Janelle M. Lugo, Nicholas C. Glodosky. Hayden R. Wright, Samantha L. Baglot, Gavin N. Petrie, Yu Zhiha, Brian H. Clowers, Carrie Cuttler, Rita A. Fuchs, Matthew N. Hill, and Ryan J. McLaughlin.

Effect of Repeated Exposure to Alcohol on the Response of the Hypothalamic-Pituitary-Adrenal Axis of the Rat: II. Role of the Length and Regimen of Alcohol Treatment

Catherine Rivier and Soon Lee (2001). Alcoholism: Clinical and Experimental Research. 25:106-111.

Tolerance to hypothermic and antinoceptive effects of ∆9 ‐tetrahydrocannabinol (THC) vapor inhalation in rats

Repeated daily THC inhalation induces tolerance in female and male rates, providing further validation of the vapor inhalation method for preclinical studies.

Compulsive-Like Sufentanil Vapor Self-Administration in Rats

Opioid misuse is at historically high levels in the United States, with inhalation (i.e. smoking and vaping) being one of the most common routes of consumption.

Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration

de Guglielmo G, Kallupi M, Cole M, George O. Psychopharmacology (Berl). 2017 Jul;234(13):2009-2018. doi: 10.1007/s00213-017-4608-7. Epub 2017 Mar 24.

Locomotor Stimulant and Rewarding Effects of Inhaling Methamphetamine, MDPV, and Mephedrone via Electronic Cigarette-Type Technology

Nguyen JD, Aarde SM, Cole M, Vandewater SA, Grant Y, Taffe MA. Neuropsychopharmacology. 2016 Oct;41(11);279-71. doi: 10.1038/npp.2016.88. Epub 2016 Jun 9.

Exposure to chronic intermittent nicotine vapor induces nicotine dependence

George O, Grieder TE, Cole M, Koob GF. Pharmacol Biochem Behav. 2010 Jul;96(1):104-7. doi: 10.1016/j.pbb.2010.04.013. Epub 2010 Apr 24.

Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41)

Finn DA, Snelling C, Fretwell AM, Tanchuck MA, Underwood L, Cole M, Crabbe JC, Roberts AJ. Alcohol Clin Exp Res. 2007 Jun;31(6):939-49. Epub 2007 Mar 31.

Effects of nicotine and THC vapor inhalation administered by an electronic nicotine delivery system (ENDS) in male rats

Mehrak Javadi-Paydar, Tony M. Kerr, Eric L. Harvey, Maury Cole, Michael A. Taffe - 1) Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA. 2) La Jolla Alcohol Research, Inc., La Jolla, CA, USA.

Vapor exposure to Δ9-tetrahydrocannabinol (THC) slows locomotion of the Maine lobster (Homarus americanus)

Arnold Gutierrez, Kevin M. Creehan, Mitchell L. Turner, Rachelle N. Tran, Tony M. Kerr, Jacques D. Nguyen, Michael A. Taffe

Fentanyl vapor self-administration model in mice to study opioid addiction

K. Moussawi, M. M. Ortiz, S. C. Gantz, B. J. Tunstall, R. C. N. Marchette, A. Bonci, G. F. Koob, L. F. Vendruscolo.

Effects of vapor exposure to Δ9-tetrahydrocannabinol (THC) in the Maine Lobster (Homarus americanus)

Arnold Gutierrez, Kevin M Creehan, Mitchell Turner, Rachelle N Tran, Tony M Kerr, Jacques D Nguyen, Michael A Taffe.

Nicotine e-cigarette vapor inhalation effects on nicotine & cotinine plasma levels and somatic withdrawal signs in adult male Wistar rats

Christian Montanari, Leslie K. Kelley, Tony M. Kerr, Maury Cole, and Nicholas W. Gilpin.

Alcohol dependence activates ventral tegmental area projections to central amygdala in male mice and rats

Elizabeth M Avegno, Chelsea R Katsen, William B Snyder, Leslie K Kelley, Thomas D Lobell, Taylor J Templeton, Michael Constans, Tiffany A Wills, Jason W Middleton, Nicholas W Gilpin.

Translation models of cannabinoid vapor exposure in laboratory animals

Moore, Catherine F., Stiltner, Jeffery W., Davis Catherine M., Weerts, Elise M. Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine. Bethesda, Maryland, USA.

Combined vapor exposure to THC and alcohol in pregnant rats: Maternal outcomes and pharmacokinetic effects

Kristen R. Breit, Cristina Rodriguez, Annie Lei, Jennifer D. Thomas. Center for Behavioral Teratology, Dept. of Psychology, San Diego State University, USA.

Female rats self-administer heroin by vapor inhalation

Gutierrez, A., Nguyen, J.D., Creehan, K.M., and Taffe, M.A. Pharmacol Biochem Behav, 2020.

Repeated nicotine vapor inhalation induces behavioral sensitization in male and female C57BL/6 mice

Sarah C. Honeycutt, Patrick I. Garrett, Allyson G. Barraza, Andrew N. Maloy and Todd M. Hillhouse.

Effects of nicotine and THC vapor inhalation administered by an electronic nicotine delivery system (ENDS) in male rats

Mehrak Javadi-Paydar, Tony M. Kerr, Eric L. Harvey, Maury Cole, and Michael A. Taffe. - 1) Department of Neuroscience, The Scripps Research Institute, La Jolla, California. 2) La Jolla Alcohol Research, Inc., La Jolla, California.

Lasting effects of repeated ∆9 ‐tetrahydrocannabinol vapour inhalation during adolescence in male and female rats

Jacques D. Nguyen, Kevin M. Creehan, Tony M. Kerr, Michael A. Taffe - 1) Department of Neuroscience, The Scripps Research Institute, La Jolla, California. 2) Department of Psychiatry, University of California, La Jolla, California. United States Public Health Service, Grant/Award Numbers: R01 DA035482, R01 DA035281 and R44 DA041967.

Methodology Papers for Rat Inhalation System

Soon Lee, Donné Schmidt, Fred Tilders, Maury Cole, Amanda Smith, and Catherine Rivier (2000). Alcoholism: Clinical and Experimental Research. 24:110-122.

Development of Individual Alcohol Inhalation Chambers for Mice: Validation in a Model of Prenatal Alcohol

Sang Soo Kang, Maury Cole, Soon Lee, and Catherine Rivier (2004). Alcoholism: Clinical and Experimental Research. 28:1549-1556.

Effects of Δ9-THC and cannabidiol vapor inhalation in male and female rats

In summary, the inhalation of THC or CBD, alone and in combination, produces approximately equivalent effects in male and female rats. This confirms the efficacy of the e-cigarette-based method of THC delivery in female rats.

Intermittent Access to Ethanol Drinking Facilitates the Transition to Excessive Drinking After Chronic Intermittent Ethanol Vapor Exposure

Kimbrough A, Kim S, Cole M, Brennan M, George O. Alcohol Clin Exp Res. 2017 Aug;41(8):1502-1509. doi: 10.1111/acer.13434. Epub 2017 Jul 5.